Devotees worship Sree Dhanwanthari with a lot of devotion to cure their ailments. According to Indian concept, Sree Dhanwanthari is the Lord of Ayurveda, a system of traditional medicine native to India. Good health is prime for long life of all the species on the earth. Health means the status of no ailments and to maintain the status of no ailments, blessings of God almighty is imperative. Veda being the way to know the God and Ayurveda as an Upaveda, it is the base for Indian Style of Medicine.

According to Puranas, due to the curse of Sree Durvasa Rishi, the Devas in the heaven lost their youthfulness and became aged with ailments and those ailing Devas approached in desperation Sree Mahavishnu for deliverance. He advised for churning Palazhi to get Amruthu and consume it to cure their ailments.

When the Devas churned Palazhi (ocean of milk) with the help of Asuras, there came first, the worst poison called Halahalam and Sree Paramasivan consumed it to save the three worlds from ruin. Finally, there came Sree Mahavishnu incarnated as merciful Sree Dhanwanthari from Palazhi with Amritha Kumbam in his hands and Sree Dhanwanthari became the God of medicine. All the Ayurveda physicians see Sree Dhanwanthari as their Guru and worship with devotion. Thrissur Thaikkatu Mooss worshiped Sree Dhanwanthari in Peringavu as their Prime Deity of Worship. Kerala has 8 prominent Ashtavaidyans and the most prominent of them are Thaikkatu Mooss and Kuttancheri Mooss. All of them worshiped Sree Dhanwanthari as their Physician God who is also another incarnation of Sree Mahavishnu.